Deacetylation of TFEB promotes fibrillar Aβ degradation by upregulating lysosomal biogenesis in microglia

Microglia play a pivotal role in clearance of Aβ by degrading them in lysosomes, countering amyloid plaque pathogenesis in Alzheimer’s disease (AD). Recent evidence suggests that lysosomal dysfunction leads to insufficient elimination of toxic protein aggregates. We tested whether enhancing lysosoma...

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Veröffentlicht in:Protein Cell
Hauptverfasser: Bao, Jintao, Zheng, Liangjun, Zhang, Qi, Li, Xinya, Zhang, Xuefei, Li, Zeyang, Bai, Xue, Zhang, Zhong, Huo, Wei, Zhao, Xuyang, Shang, Shujiang, Wang, Qingsong, Zhang, Chen, Ji, Jianguo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Higher Education Press 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4887328/
https://ncbi.nlm.nih.gov/pubmed/27209302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13238-016-0269-2
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