Deacetylation of TFEB promotes fibrillar Aβ degradation by upregulating lysosomal biogenesis in microglia

Microglia play a pivotal role in clearance of Aβ by degrading them in lysosomes, countering amyloid plaque pathogenesis in Alzheimer’s disease (AD). Recent evidence suggests that lysosomal dysfunction leads to insufficient elimination of toxic protein aggregates. We tested whether enhancing lysosoma...

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Detalhes bibliográficos
Publicado no:Protein Cell
Main Authors: Bao, Jintao, Zheng, Liangjun, Zhang, Qi, Li, Xinya, Zhang, Xuefei, Li, Zeyang, Bai, Xue, Zhang, Zhong, Huo, Wei, Zhao, Xuyang, Shang, Shujiang, Wang, Qingsong, Zhang, Chen, Ji, Jianguo
Formato: Artigo
Idioma:Inglês
Publicado em: Higher Education Press 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4887328/
https://ncbi.nlm.nih.gov/pubmed/27209302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13238-016-0269-2
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