Activated Cyclin-Dependent Kinase 5 Promotes Microglial Phagocytosis of Fibrillar β-Amyloid by Up-regulating Lipoprotein Lipase Expression

Amyloid plaques are crucial for the pathogenesis of Alzheimer disease (AD). Phagocytosis of fibrillar β-amyloid (Aβ) by activated microglia is essential for Aβ clearance in Alzheimer disease. However, the mechanism underlying Aβ clearance in the microglia remains unclear. In this study, we performed...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Ma, Yuanhui, Bao, Jintao, Zhao, Xuyang, Shen, Hongyan, Lv, Junniao, Ma, Shuaipeng, Zhang, Xuefei, Li, Zeyang, Wang, Shuxin, Wang, Qingsong, Ji, Jianguo
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: The American Society for Biochemistry and Molecular Biology 2013
Θέματα:
Research
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3790294/
https://ncbi.nlm.nih.gov/pubmed/23816988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M112.026864
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