Activated Cyclin-Dependent Kinase 5 Promotes Microglial Phagocytosis of Fibrillar β-Amyloid by Up-regulating Lipoprotein Lipase Expression

Amyloid plaques are crucial for the pathogenesis of Alzheimer disease (AD). Phagocytosis of fibrillar β-amyloid (Aβ) by activated microglia is essential for Aβ clearance in Alzheimer disease. However, the mechanism underlying Aβ clearance in the microglia remains unclear. In this study, we performed...

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Bibliographic Details
Main Authors: Ma, Yuanhui, Bao, Jintao, Zhao, Xuyang, Shen, Hongyan, Lv, Junniao, Ma, Shuaipeng, Zhang, Xuefei, Li, Zeyang, Wang, Shuxin, Wang, Qingsong, Ji, Jianguo
Format: Artigo
Language:Inglês
Published: The American Society for Biochemistry and Molecular Biology 2013
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3790294/
https://ncbi.nlm.nih.gov/pubmed/23816988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M112.026864
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