PGC-1α/ERRα-Sirt3 Pathway Regulates DAergic Neuronal Death by Directly Deacetylating SOD2 and ATP Synthase β

Aims: Parkinson's disease (PD) heavily affects humans and little is known about its cause and pathogenesis. Sirtuin 3 (Sirt3) plays a key role in regulating mitochondrial dysfunction, which is the main cause of DAergic neuronal loss in PD. We investigated the mechanisms of neuroprotective role...

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Detalhes bibliográficos
Publicado no:Antioxid Redox Signal
Main Authors: Zhang, Xuefei, Ren, Xiaoqing, Zhang, Qi, Li, Zheyi, Ma, Shuaipeng, Bao, Jintao, Li, Zeyang, Bai, Xue, Zheng, Liangjun, Zhang, Zhong, Shang, Shujiang, Zhang, Chen, Wang, Chuangui, Cao, Liu, Wang, Qingsong, Ji, Jianguo
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2016
Assuntos:
Original Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4761832/
https://ncbi.nlm.nih.gov/pubmed/26421366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2015.6403
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