The TIP60 complex regulates bivalent chromatin recognition by 53BP1 through direct H4K20me binding and H2AK15 acetylation

The NuA4/TIP60 acetyltransferase complex is a key regulator of genome expression and stability. Here, we identified MBTD1 as a new stable subunit of the complex and gleaned intriguing insights into TIP60’s function. Harboring a histone reader domain for H4K20me1/2, MBTD1 allows TIP60 to associate wi...

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Pubblicato in:Mol Cell
Autori principali: Jacquet, Karine, Fradet-Turcotte, Amélie, Avvakumov, Nikita, Lambert, Jean-Philippe, Roques, Céline, Pandita, Raj K., Paquet, Eric, Herst, Pauline, Gingras, Anne-Claude, Pandita, Tej K., Legube, Gaëlle, Doyon, Yannick, Durocher, Daniel, Côté, Jacques
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4887106/
https://ncbi.nlm.nih.gov/pubmed/27153538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.03.031
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