MOF and Histone H4 Acetylation at Lysine 16 Are Critical for DNA Damage Response and Double-Strand Break Repair

The human MOF gene encodes a protein that specifically acetylates histone H4 at lysine 16 (H4K16ac). Here we show that reduced levels of H4K16ac correlate with a defective DNA damage response (DDR) and double-strand break (DSB) repair to ionizing radiation (IR). The defect, however, is not due to al...

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Main Authors: Sharma, Girdhar G., So, Sairei, Gupta, Arun, Kumar, Rakesh, Cayrou, Christelle, Avvakumov, Nikita, Bhadra, Utpal, Pandita, Raj K., Porteus, Matthew H., Chen, David J., Cote, Jacques, Pandita, Tej K.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2010
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2897562/
https://ncbi.nlm.nih.gov/pubmed/20479123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01476-09
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