MOF and Histone H4 Acetylation at Lysine 16 Are Critical for DNA Damage Response and Double-Strand Break Repair

The human MOF gene encodes a protein that specifically acetylates histone H4 at lysine 16 (H4K16ac). Here we show that reduced levels of H4K16ac correlate with a defective DNA damage response (DDR) and double-strand break (DSB) repair to ionizing radiation (IR). The defect, however, is not due to al...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Sharma, Girdhar G., So, Sairei, Gupta, Arun, Kumar, Rakesh, Cayrou, Christelle, Avvakumov, Nikita, Bhadra, Utpal, Pandita, Raj K., Porteus, Matthew H., Chen, David J., Cote, Jacques, Pandita, Tej K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2897562/
https://ncbi.nlm.nih.gov/pubmed/20479123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01476-09
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados