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Ubiquitin-mediated fluctuations in MHC class II facilitate efficient germinal center B cell responses
Antibody affinity maturation occurs in germinal centers (GCs) through iterative rounds of somatic hypermutation and selection. Selection involves B cells competing for T cell help based on the amount of antigen they capture and present on their MHC class II (MHCII) proteins. How GC B cells are able...
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| Udgivet i: | J Exp Med |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Rockefeller University Press
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4886361/ https://ncbi.nlm.nih.gov/pubmed/27162138 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20151682 |
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