Ubiquitination regulates MHC class II-peptide complex retention and degradation in dendritic cells

The expression and turnover of MHC class II-peptide complexes (pMHC-II) on the surface of dendritic cells (DCs) is essential for their ability to activate CD4 T cells efficiently. The half-life of surface pMHC-II is significantly greater in activated (mature) DCs than in resting (immature) DCs, but...

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Detalhes bibliográficos
Main Authors: Walseng, Even, Furuta, Kazuyuki, Bosch, Berta, Weih, Karis A., Matsuki, Yohei, Bakke, Oddmund, Ishido, Satoshi, Roche, Paul A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2996684/
https://ncbi.nlm.nih.gov/pubmed/21059907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1010990107
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