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Ubiquitination regulates MHC class II-peptide complex retention and degradation in dendritic cells
The expression and turnover of MHC class II-peptide complexes (pMHC-II) on the surface of dendritic cells (DCs) is essential for their ability to activate CD4 T cells efficiently. The half-life of surface pMHC-II is significantly greater in activated (mature) DCs than in resting (immature) DCs, but...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2996684/ https://ncbi.nlm.nih.gov/pubmed/21059907 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1010990107 |
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