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Internalizing MHC class II–peptide complexes are ubiquitinated in early endosomes and targeted for lysosomal degradation

As sentinels of the immune system, dendritic cells (DCs) continuously generate and turnover antigenic peptide–MHC class II complexes (pMHC-II). pMHC-II generation is a complex process that involves many well-characterized MHC-II biosynthetic intermediates; however, the mechanisms leading to MHC-II t...

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Bibliografske podrobnosti
Main Authors: Furuta, Kazuyuki, Walseng, Even, Roche, Paul A.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3864281/
https://ncbi.nlm.nih.gov/pubmed/24277838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1312994110
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