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Internalizing MHC class II–peptide complexes are ubiquitinated in early endosomes and targeted for lysosomal degradation
As sentinels of the immune system, dendritic cells (DCs) continuously generate and turnover antigenic peptide–MHC class II complexes (pMHC-II). pMHC-II generation is a complex process that involves many well-characterized MHC-II biosynthetic intermediates; however, the mechanisms leading to MHC-II t...
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| Autores principales: | , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
2013
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3864281/ https://ncbi.nlm.nih.gov/pubmed/24277838 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1312994110 |
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