Ubiquitin-mediated fluctuations in MHC class II facilitate efficient germinal center B cell responses

Antibody affinity maturation occurs in germinal centers (GCs) through iterative rounds of somatic hypermutation and selection. Selection involves B cells competing for T cell help based on the amount of antigen they capture and present on their MHC class II (MHCII) proteins. How GC B cells are able...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Exp Med
Prif Awduron: Bannard, Oliver, McGowan, Simon J., Ersching, Jonatan, Ishido, Satoshi, Victora, Gabriel D., Shin, Jeoung-Sook, Cyster, Jason G.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Rockefeller University Press 2016
Pynciau:
Research Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4886361/
https://ncbi.nlm.nih.gov/pubmed/27162138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20151682
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