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Nanoparticle Delivered Human Biliverdin Reductase-Based Peptide Increases Glucose Uptake by Activating IRK/Akt/GSK3 Axis: The Peptide Is Effective in the Cell and Wild-Type and Diabetic Ob/Ob Mice

Insulin's stimulation of glucose uptake by binding to the IRK extracellular domain is compromised in diabetes. We have recently described an unprecedented approach to stimulating glucose uptake. KYCCSRK (P2) peptide, corresponding to the C-terminal segment of hBVR, was effective in binding to a...

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書目詳細資料
發表在:J Diabetes Res
Main Authors: Gibbs, Peter E. M., Miralem, Tihomir, Lerner-Marmarosh, Nicole, Maines, Mahin D.
格式: Artigo
語言:Inglês
出版: Hindawi Publishing Corporation 2016
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4886063/
https://ncbi.nlm.nih.gov/pubmed/27294151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/4712053
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