The Human Biliverdin Reductase-based Peptide Fragments and Biliverdin Regulate Protein Kinase Cδ Activity: THE PEPTIDES ARE INHIBITORS OR SUBSTRATE FOR THE PROTEIN KINASE C

PKCδ, a Ser/Thr kinase, promotes cell growth, tumorigenesis, and apoptosis. Human biliverdin reductase (hBVR), a Ser/Thr/Tyr kinase, inhibits apoptosis by reducing biliverdin-IX to antioxidant bilirubin. The enzymes are activated by similar stimuli. Reportedly, hBVR is a kinase-independent activator...

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Detalhes bibliográficos
Main Authors: Miralem, Tihomir, Lerner-Marmarosh, Nicole, Gibbs, Peter E. M., Tudor, Cicerone, Hagen, Fred K., Maines, Mahin D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3397897/
https://ncbi.nlm.nih.gov/pubmed/22584576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.326504
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