Nanoparticle Delivered Human Biliverdin Reductase-Based Peptide Increases Glucose Uptake by Activating IRK/Akt/GSK3 Axis: The Peptide Is Effective in the Cell and Wild-Type and Diabetic Ob/Ob Mice

Insulin's stimulation of glucose uptake by binding to the IRK extracellular domain is compromised in diabetes. We have recently described an unprecedented approach to stimulating glucose uptake. KYCCSRK (P2) peptide, corresponding to the C-terminal segment of hBVR, was effective in binding to a...

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Veröffentlicht in:J Diabetes Res
Hauptverfasser: Gibbs, Peter E. M., Miralem, Tihomir, Lerner-Marmarosh, Nicole, Maines, Mahin D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hindawi Publishing Corporation 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4886063/
https://ncbi.nlm.nih.gov/pubmed/27294151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/4712053
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