Interaction of human biliverdin reductase with Akt/protein kinase B and phosphatidylinositol-dependent kinase 1 regulates glycogen synthase kinase 3 activity: a novel mechanism of Akt activation

Biliverdin reductase A (BVR) and Akt isozymes have overlapping pleiotropic functions in the insulin/PI3K/MAPK pathway. Human BVR (hBVR) also reduces the hemeoxygenase activity product biliverdin to bilirubin and is directly activated by insulin receptor kinase (IRK). Akt isoenzymes (Akt1–3) are down...

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Bibliographische Detailangaben
Veröffentlicht in:FASEB J
Hauptverfasser: Miralem, Tihomir, Lerner-Marmarosh, Nicole, Gibbs, Peter E. M., Jenkins, Jermaine L., Heimiller, Chelsea, Maines, Mahin D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Federation of American Societies for Experimental Biology 2016
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4970609/
https://ncbi.nlm.nih.gov/pubmed/27166089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201600330RR
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