Human biliverdin reductase is an ERK activator; hBVR is an ERK nuclear transporter and is required for MAPK signaling

Activation of the MEK/ERK/Elk-signaling cascade is a mechanism for relaying mitogenic and stress stimuli for gene activation. MEK1 is the proximate kinase for activation of ERK1/2, and nuclear targeting of ERK1/2 is obligatory for Elk1 transcriptional activity. Human biliverdin reductase (hBVR) is a...

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Bibliographische Detailangaben
Hauptverfasser: Lerner-Marmarosh, Nicole, Miralem, Tihomir, Gibbs, Peter E. M., Maines, Mahin D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2008
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2383961/
https://ncbi.nlm.nih.gov/pubmed/18463290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0800750105
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