Effects of N-Substitutions on the Tetrahydroquinoline (THQ) Core of Mixed-Efficacy μ-Opioid Receptor (MOR)/δ-Opioid Receptor (DOR) Ligands

[Image: see text] N-Acetylation of the tetrahydroquinoline (THQ) core of a series of μ-opioid receptor (MOR) agonist/δ-opioid receptor (DOR) antagonist ligands increases DOR affinity, resulting in ligands with balanced MOR and DOR affinities. We report a series of N-substituted THQ analogues that in...

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Pubblicato in:J Med Chem
Autori principali: Harland, Aubrie A., Bender, Aaron M., Griggs, Nicholas W., Gao, Chao, Anand, Jessica P., Pogozheva, Irina D., Traynor, John R., Jutkiewicz, Emily M., Mosberg, Henry I.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2016
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4885601/
https://ncbi.nlm.nih.gov/pubmed/27148755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b00308
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