Asymmetric Synthesis and In Vitro and In Vivo Activity of Tetrahydroquinolines Featuring a Diverse Set of Polar Substitutions at the 6 Position as Mixed Efficacy μ Opioid Receptor/δ Opioid Receptor Ligands

We have previously reported a small series of mixed efficacy μ opioid receptor (MOR) agonist/δ opioid receptor (DOR) antagonist opioid peptidomimetics featuring a tetrahydroquinoline (THQ) scaffold, and showed the promise of this series as effective analgesics after intraperitoneal administration in...

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發表在:ACS Chem Neurosci
Main Authors: Bender, Aaron M., Griggs, Nicholas W., Anand, Jessica P., Traynor, John R., Jutkiewicz, Emily M., Mosberg, Henry I.
格式: Artigo
語言:Inglês
出版: 2015
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4676711/
https://ncbi.nlm.nih.gov/pubmed/25938166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.5b00100
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