Assessing Colonic Exposure, Safety, and Clinical Activity of SRT2104, a Novel Oral SIRT1 Activator, in Patients with Mild to Moderate Ulcerative Colitis

BACKGROUND: Sirtuins are a class of proteins with important physiologic roles in metabolism and inflammation. Sirtuin (silent mating type information regulation 2 homolog) 1, or SIRT1, activation is an unexplored therapeutic approach for the treatment of ulcerative colitis (UC). METHODS: Patients wi...

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Vydáno v:Inflamm Bowel Dis
Hlavní autoři: Sands, Bruce E., Joshi, Shashidhar, Haddad, Jonathan, Freudenberg, Johannes M., Oommen, Deepa Elizabeth, Hoffmann, Ethan, McCallum, Stewart W., Jacobson, Eric
Médium: Artigo
Jazyk:Inglês
Vydáno: Lippincott Williams & Wilkins 2015
Témata:
Original Clinical Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4885523/
https://ncbi.nlm.nih.gov/pubmed/26595549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MIB.0000000000000597
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