Pharmacokinetics and tolerability of SRT2104, a first-in-class small molecule activator of SIRT1, after single and repeated oral administration in man

AIM: SRT2104 is a novel, first-in-class, highly selective small molecule activator of the NAD + dependent deacetylase SIRT1. SRT2104 was dosed to healthy male and female volunteers in a series of phase 1 clinical studies that were designed to elucidate tolerability and pharmacokinetics associated wi...

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Detalhes bibliográficos
Main Authors: Hoffmann, Ethan, Wald, Jeff, Lavu, Siva, Roberts, John, Beaumont, Claire, Haddad, Jon, Elliott, Peter, Westphal, Christoph, Jacobson, Eric
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2013
Assuntos:
Pharmacokinetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3555058/
https://ncbi.nlm.nih.gov/pubmed/22616762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2012.04340.x
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