A phase II, randomized, placebo-controlled, double-blind, multi-dose study of SRT2104, a SIRT1 activator, in subjects with type 2 diabetes

AIM: SRT2104 is a selective activator of SIRT1. In animal models, SRT2104 improves glucose homeostasis and increases insulin sensitivity. We evaluated the tolerability and pharmacokinetics of SRT2104, and its effects on glycaemic control, in adults with type 2 diabetes mellitus. METHOD: Type 2 diabe...

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Detalhes bibliográficos
Main Authors: Baksi, Arun, Kraydashenko, Oleg, Zalevkaya, Alsu, Stets, Roman, Elliott, Peter, Haddad, Jonathan, Hoffmann, Ethan, Vlasuk, George P, Jacobson, Eric W
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2014
Assuntos:
Pharmacodynamics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4168381/
https://ncbi.nlm.nih.gov/pubmed/24446723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12327
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