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Analysis of β-Subunit-dependent GABA(A) Receptor Modulation and Behavioral Effects of Valerenic Acid Derivatives
Valerenic acid (VA)—a β2/3-selective GABA type A (GABA(A)) receptor modulator—displays anxiolytic and anticonvulsive effects in mice devoid of sedation, making VA an interesting drug candidate. Here we analyzed β-subunit-dependent enhancement of GABA-induced chloride currents (I(GABA)) by a library...
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| 出版年: | J Pharmacol Exp Ther |
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| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The American Society for Pharmacology and Experimental Therapeutics
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4885513/ https://ncbi.nlm.nih.gov/pubmed/27190170 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.116.232983 |
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