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Identification of the putative binding pocket of valerenic acid on GABA(A) receptors using docking studies and site‐directed mutagenesis
BACKGROUND AND PURPOSE: β2/3‐subunit‐selective modulation of GABA(A) receptors by valerenic acid (VA) is determined by the presence of transmembrane residue β2/3N265. Currently, it is not known whether β2/3N265 is part of VA's binding pocket or is involved in the transduction pathway of VA'...
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| Veröffentlicht in: | Br J Pharmacol |
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| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
John Wiley and Sons Inc.
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4988470/ https://ncbi.nlm.nih.gov/pubmed/26375408 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13329 |
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