Identification of the putative binding pocket of valerenic acid on GABA(A) receptors using docking studies and site‐directed mutagenesis

BACKGROUND AND PURPOSE: β2/3‐subunit‐selective modulation of GABA(A) receptors by valerenic acid (VA) is determined by the presence of transmembrane residue β2/3N265. Currently, it is not known whether β2/3N265 is part of VA's binding pocket or is involved in the transduction pathway of VA'...

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Bibliografske podrobnosti
izdano v:Br J Pharmacol
Main Authors: Luger, D, Poli, G, Wieder, M, Stadler, M, Ke, S, Ernst, M, Hohaus, A, Linder, T, Seidel, T, Langer, T, Khom, S, Hering, S
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2015
Teme:
Research Papers
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4988470/
https://ncbi.nlm.nih.gov/pubmed/26375408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13329
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