Esters of valerenic acid as potential prodrugs

Valerenic acid (VA) is a β(2/3) subunit-specific modulator of γ-aminobutyric acid (GABA) type A (GABA(A)) receptors inducing anxiolysis. Here we analyze if VA-esters can serve as prodrugs and if different ester structures have different in vitro/in vivo effects. Modulation of GABA(A) receptors expre...

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Autores principales: Hintersteiner, Juliane, Haider, Maximilian, Luger, Denise, Schwarzer, Christoph, Reznicek, Gottfried, Jäger, Walter, Khom, Sophia, Mihovilovic, Marko D., Hering, Steffen
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier Science 2014
Materias:
Behavioural Pharmacology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4062961/
https://ncbi.nlm.nih.gov/pubmed/24680924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2014.03.019
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