Analysis of β-Subunit-dependent GABA(A) Receptor Modulation and Behavioral Effects of Valerenic Acid Derivatives

Valerenic acid (VA)—a β2/3-selective GABA type A (GABA(A)) receptor modulator—displays anxiolytic and anticonvulsive effects in mice devoid of sedation, making VA an interesting drug candidate. Here we analyzed β-subunit-dependent enhancement of GABA-induced chloride currents (I(GABA)) by a library...

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Pubblicato in:J Pharmacol Exp Ther
Autori principali: Khom, S., Hintersteiner, J., Luger, D., Haider, M., Pototschnig, G., Mihovilovic, M. D., Schwarzer, C., Hering, S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Pharmacology and Experimental Therapeutics 2016
Soggetti:
Behavioral Pharmacology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4885513/
https://ncbi.nlm.nih.gov/pubmed/27190170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.116.232983
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