Anti-Ulcer Efficacy of Soluble Epoxide Hydrolase Inhibitor TPPU on Diclofenac-Induced Intestinal Ulcers

Proton pump inhibitors such as omeprazole (OME) reduce the severity of gastrointestinal (GI) ulcers induced by nonsteroidal anti-inflammatory drugs (NSAIDs) but can also increase the chance of dysbiosis. The aim of this study was to test the hypothesis that preventive use of a soluble epoxide hydrol...

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Vydáno v:J Pharmacol Exp Ther
Hlavní autoři: Goswami, Sumanta Kumar, Wan, Debin, Yang, Jun, Trindade da Silva, Carlos A., Morisseau, Christophe, Kodani, Sean D., Yang, Guang-Yu, Inceoglu, Bora, Hammock, Bruce D.
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Pharmacology and Experimental Therapeutics 2016
Témata:
Gastrointestinal, Hepatic, Pulmonary, and Renal
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4885505/
https://ncbi.nlm.nih.gov/pubmed/26989141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.116.232108
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