Pharmacological inhibition of soluble epoxide hydrolase or genetic deletion reduces diclofenac-induced gastric ulcers

AIMS: This research was conducted to evaluate the hypothesis that gastric ulcers caused by the NSAID diclofenac sodium (DCF) can be prevented by the soluble epoxide hydrolase inhibitor TPPU. MAIN METHODS: Mice were administered a single dose of 10, 30 or 100 mg/kg of DCF. Once an ulcerative dose of...

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Detalhes bibliográficos
Publicado no:Life Sci
Main Authors: Goswami, Sumanta Kumar, Rand, Amelia Ann, Wan, Debin, Yang, Jun, Inceoglu, Bora, Thomas, Melany, Morisseau, Christophe, Yang, Guang-Yu, Hammock, Bruce D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5659729/
https://ncbi.nlm.nih.gov/pubmed/28522175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.lfs.2017.05.018
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