Omeprazole increases the efficacy of a soluble epoxide hydrolase inhibitor in a PGE(2) induced pain model

Epoxyeicosatrienoic acids (EETs) are potent endogenous analgesic metabolites produced from arachidonic acid by cytochrome P450s (P450s). Metabolism of EETs by soluble epoxide hydrolase (sEH) reduces their activity, while their stabilization by sEH inhibition decreases both inflammatory and neuropath...

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Pubblicato in:Toxicol Appl Pharmacol
Autori principali: Goswami, Sumanta Kumar, Inceoglu, Bora, Yang, Jun, Wan, Debin, Kodani, Sean D., da Silva, Carlos Antonio Trindade, Morisseau, Christophe, Hammock, Bruce D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4666679/
https://ncbi.nlm.nih.gov/pubmed/26522832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2015.10.018
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