Valproic acid potentiates the anticancer activity of capecitabine in vitro and in vivo in breast cancer models via induction of thymidine phosphorylase expression

The prognosis of patients with metastatic breast cancer remains poor, and thus novel therapeutic approaches are needed. Capecitabine, which is commonly used for metastatic breast cancer in different settings, is an inactive prodrug that takes advantage of elevated levels of thymidine phosphorylase (...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Terranova-Barberio, Manuela, Roca, Maria Serena, Zotti, Andrea Ilaria, Leone, Alessandra, Bruzzese, Francesca, Vitagliano, Carlo, Scogliamiglio, Giosuè, Russo, Domenico, D'Angelo, Giovanni, Franco, Renato, Budillon, Alfredo, Di Gennaro, Elena
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4884949/
https://ncbi.nlm.nih.gov/pubmed/26735339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6802
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