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Crosstalk between Ca(2+) signaling and mitochondrial H(2)O(2) is required for rotenone inhibition of mTOR signaling pathway leading to neuronal apoptosis
Rotenone, a neurotoxic pesticide, induces loss of dopaminergic neurons related to Parkinson's disease. Previous studies have shown that rotenone induces neuronal apoptosis partly by triggering hydrogen peroxide (H(2)O(2))-dependent suppression of mTOR pathway. However, the underlying mechanism...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Oncotarget |
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| Κύριοι συγγραφείς: | , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Impact Journals LLC
2016
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4884936/ https://ncbi.nlm.nih.gov/pubmed/26859572 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7183 |
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