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Directly Activating the Integrin αIIbβ3 Initiates Outside-In Signaling by Causing αIIbβ3 Clustering

αIIbβ3 activation in platelets is followed by activation of the tyrosine kinase c-Src associated with the carboxyl terminus of the β3 cytosolic tail. Exogenous peptides designed to interact with the αIIb transmembrane (TM) domain activate single αIIbβ3 molecules in platelets by binding to the αIIb T...

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Detaylı Bibliyografya
Yayımlandı:J Biol Chem
Asıl Yazarlar: Fong, Karen P., Zhu, Hua, Span, Lisa M., Moore, David T., Yoon, Kyungchul, Tamura, Ryo, Yin, Hang, DeGrado, William F., Bennett, Joel S.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2016
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4882439/
https://ncbi.nlm.nih.gov/pubmed/27056329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.716613
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