Directly Activating the Integrin αIIbβ3 Initiates Outside-In Signaling by Causing αIIbβ3 Clustering

αIIbβ3 activation in platelets is followed by activation of the tyrosine kinase c-Src associated with the carboxyl terminus of the β3 cytosolic tail. Exogenous peptides designed to interact with the αIIb transmembrane (TM) domain activate single αIIbβ3 molecules in platelets by binding to the αIIb T...

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Vydáno v:J Biol Chem
Hlavní autoři: Fong, Karen P., Zhu, Hua, Span, Lisa M., Moore, David T., Yoon, Kyungchul, Tamura, Ryo, Yin, Hang, DeGrado, William F., Bennett, Joel S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2016
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4882439/
https://ncbi.nlm.nih.gov/pubmed/27056329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.716613
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