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Directly Activating the Integrin αIIbβ3 Initiates Outside-In Signaling by Causing αIIbβ3 Clustering

αIIbβ3 activation in platelets is followed by activation of the tyrosine kinase c-Src associated with the carboxyl terminus of the β3 cytosolic tail. Exogenous peptides designed to interact with the αIIb transmembrane (TM) domain activate single αIIbβ3 molecules in platelets by binding to the αIIb T...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:J Biol Chem
मुख्य लेखकों: Fong, Karen P., Zhu, Hua, Span, Lisa M., Moore, David T., Yoon, Kyungchul, Tamura, Ryo, Yin, Hang, DeGrado, William F., Bennett, Joel S.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society for Biochemistry and Molecular Biology 2016
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4882439/
https://ncbi.nlm.nih.gov/pubmed/27056329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.716613
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