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AbDesign: an algorithm for combinatorial backbone design guided by natural conformations and sequences

Computational design of protein function has made substantial progress, generating new enzymes, binders, inhibitors, and nanomaterials not previously seen in nature. However, the ability to design new protein backbones for function – essential to exert control over all polypeptide degrees of freedom...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Proteins
Hauptverfasser: Lapidoth, Gideon D., Baran, Dror, Pszolla, Gabriele M., Norn, Christoffer, Alon, Assaf, Tyka, Michael D., Fleishman, Sarel J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4881815/
https://ncbi.nlm.nih.gov/pubmed/25670500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.24779
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