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Histone acetyltransferases: challenges in targeting bi-substrate enzymes

Histone acetyltransferases (HATs) are epigenetic enzymes that install acetyl groups onto lysine residues of cellular proteins such as histones, transcription factors, nuclear receptors, and enzymes. HATs have been shown to play a role in diseases ranging from cancer and inflammatory diseases to neur...

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Détails bibliographiques
Publié dans:Clin Epigenetics
Auteurs principaux: Wapenaar, Hannah, Dekker, Frank J.
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2016
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4881052/
https://ncbi.nlm.nih.gov/pubmed/27231488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-016-0225-2
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