NLRP3 Deficiency Reduces Macrophage Interleukin-10 Production and Enhances the Susceptibility to Doxorubicin-induced Cardiotoxicity

NLRP3 inflammasomes recognize non-microbial danger signals and induce release of proinflammatory cytokine interleukin (IL)-1β, leading to sterile inflammation in cardiovascular disease. Because sterile inflammation is involved in doxorubicin (Dox)-induced cardiotoxicity, we investigated the role of...

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Publicado en:Sci Rep
Autores principales: Kobayashi, Motoi, Usui, Fumitake, Karasawa, Tadayoshi, Kawashima, Akira, Kimura, Hiroaki, Mizushina, Yoshiko, Shirasuna, Koumei, Mizukami, Hiroaki, Kasahara, Tadashi, Hasebe, Naoyuki, Takahashi, Masafumi
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4880937/
https://ncbi.nlm.nih.gov/pubmed/27225830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep26489
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