Oligomerized CARD16 promotes caspase-1 assembly and IL-1β processing

Increasing evidence indicates that caspase recruitment domain (CARD)-mediated caspase-1 (CASP1) assembly is an essential process for its activation and subsequent interleukin (IL)-1β release, leading to the initiation of inflammation. Both CARD16 and CARD17 were previously reported as inhibitory hom...

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Veröffentlicht in:FEBS Open Bio
Hauptverfasser: Karasawa, Tadayoshi, Kawashima, Akira, Usui, Fumitake, Kimura, Hiroaki, Shirasuna, Koumei, Inoue, Yoshiyuki, Komada, Takanori, Kobayashi, Motoi, Mizushina, Yoshiko, Sagara, Junji, Takahashi, Masafumi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4420773/
https://ncbi.nlm.nih.gov/pubmed/25973362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.fob.2015.04.011
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