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Nucleosome breathing and remodeling constrain CRISPR-Cas9 function
The CRISPR-Cas9 bacterial surveillance system has become a versatile tool for genome editing and gene regulation in eukaryotic cells, yet how CRISPR-Cas9 contends with the barriers presented by eukaryotic chromatin is poorly understood. Here we investigate how the smallest unit of chromatin, a nucle...
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| Publicado no: | eLife |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4880442/ https://ncbi.nlm.nih.gov/pubmed/27130520 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.13450 |
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