Prospective Design of Anti‐Transferrin Receptor Bispecific Antibodies for Optimal Delivery into the Human Brain

Anti‐transferrin receptor (TfR)‐based bispecific antibodies have shown promise for boosting antibody uptake in the brain. Nevertheless, there are limited data on the molecular properties, including affinity required for successful development of TfR‐based therapeutics. A complex nonmonotonic relatio...

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Publicado en:CPT Pharmacometrics Syst Pharmacol
Autores principales: Kanodia, JS, Gadkar, K, Bumbaca, D, Zhang, Y, Tong, RK, Luk, W, Hoyte, K, Lu, Y, Wildsmith, KR, Couch, JA, Watts, RJ, Dennis, MS, Ernst, JA, Scearce‐Levie, K, Atwal, JK, Ramanujan, S, Joseph, S
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2016
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Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4879477/
https://ncbi.nlm.nih.gov/pubmed/27299941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12081
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