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Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants

Antibodies to transferrin receptor (TfR) have potential use for therapeutic entry into the brain. We have shown that bispecific antibodies against TfR and β-secretase (BACE1 [β-amyloid cleaving enzyme-1]) traverse the blood–brain barrier (BBB) and effectively reduce brain amyloid β levels. We found...

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書誌詳細
主要な著者: Bien-Ly, Nga, Yu, Y. Joy, Bumbaca, Daniela, Elstrott, Justin, Boswell, C. Andrew, Zhang, Yin, Luk, Wilman, Lu, Yanmei, Dennis, Mark S., Weimer, Robby M., Chung, Inhee, Watts, Ryan J.
フォーマット: Artigo
言語:Inglês
出版事項: The Rockefeller University Press 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3920563/
https://ncbi.nlm.nih.gov/pubmed/24470444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20131660
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