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Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants
Antibodies to transferrin receptor (TfR) have potential use for therapeutic entry into the brain. We have shown that bispecific antibodies against TfR and β-secretase (BACE1 [β-amyloid cleaving enzyme-1]) traverse the blood–brain barrier (BBB) and effectively reduce brain amyloid β levels. We found...
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| 主要な著者: | , , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The Rockefeller University Press
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3920563/ https://ncbi.nlm.nih.gov/pubmed/24470444 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20131660 |
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