Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants

Antibodies to transferrin receptor (TfR) have potential use for therapeutic entry into the brain. We have shown that bispecific antibodies against TfR and β-secretase (BACE1 [β-amyloid cleaving enzyme-1]) traverse the blood–brain barrier (BBB) and effectively reduce brain amyloid β levels. We found...

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Bibliografiska uppgifter
Huvudupphovsmän: Bien-Ly, Nga, Yu, Y. Joy, Bumbaca, Daniela, Elstrott, Justin, Boswell, C. Andrew, Zhang, Yin, Luk, Wilman, Lu, Yanmei, Dennis, Mark S., Weimer, Robby M., Chung, Inhee, Watts, Ryan J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Rockefeller University Press 2014
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3920563/
https://ncbi.nlm.nih.gov/pubmed/24470444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20131660
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