Therapeutic Bispecific T-Cell Engager Antibody Targeting the Transferrin Receptor

Bispecific T-cell engager antibodies (BiTE) have been explored as a means to recruit cytolytic T cells to kill tumor cells. The transferrin receptor (TfR) is highly expressed on the surface of rapidly proliferating tumor cells. Therefore, it holds great potential in T cell redirecting therapies. In...

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Detalles Bibliográficos
Publicado en:Front Immunol
Autores principales: Fu, Mingpeng, He, Qi, Guo, Zilong, Zhou, Xiaoran, Li, Heli, Zhao, Liang, Tang, Hongling, Zhou, Xiaoqi, Zhu, Huifen, Shen, Guanxin, He, Yong, Lei, Ping
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6598450/
https://ncbi.nlm.nih.gov/pubmed/31293575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.01396
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