TCR signaling by conventional CD4(+) T cells is required for optimal maintenance of peripheral regulatory T cell numbers

To maintain immune tolerance, regulatory T cell (Treg) numbers must be closely indexed to the number of conventional T cells (Tconvs) so that an adequate Treg:Tconv ratio can be maintained. Two factors important in this process are the cytokine interleukin‐2 (IL‐2) and T cell receptor (TCR) stimulat...

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Vydáno v:Immun Inflamm Dis
Hlavní autoři: Leichner, Theresa M., Satake, Atsushi, Kambayashi, Taku
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2016
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4879461/
https://ncbi.nlm.nih.gov/pubmed/27891224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/iid3.100
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