Cell-autonomous role of TGFβ and IL-2 receptors in CD4(+) and CD8(+) inducible regulatory T-cell generation during GVHD

FoxP3(+) regulatory T cells (Tregs) suppress GVHD while preserving graft-versus-tumor effects, making them an attractive target for GVHD therapy. The donor-derived Treg pool can potentially be derived from the expansion of preexisting natural Tregs (nTregs) or from de novo generation of inducible Tr...

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Main Authors: Sawamukai, Norifumi, Satake, Atsushi, Schmidt, Amanda M., Lamborn, Ian T., Ojha, Priti, Tanaka, Yoshiya, Kambayashi, Taku
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2012
Assuntos:
Transplantation
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3369690/
https://ncbi.nlm.nih.gov/pubmed/22496155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-07-367987
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