Hepatitis C Virus Genotype 1 to 6 Protease Inhibitor Escape Variants: In Vitro Selection, Fitness, and Resistance Patterns in the Context of the Infectious Viral Life Cycle

Hepatitis C virus (HCV) NS3 protease inhibitors (PIs) are important components of novel HCV therapy regimens. Studies of PI resistance initially focused on genotype 1. Therefore, knowledge about the determinants of PI resistance for the highly prevalent genotypes 2 to 6 remains limited. Using Huh7.5...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Antimicrob Agents Chemother
Autori principali: Serre, Stéphanie B. N., Jensen, Sanne B., Ghanem, Lubna, Humes, Daryl G., Ramirez, Santseharay, Li, Yi-Ping, Krarup, Henrik, Bukh, Jens, Gottwein, Judith M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2016
Soggetti:
Antiviral Agents
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4879388/
https://ncbi.nlm.nih.gov/pubmed/27021330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02929-15
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