Substitutions at NS3 Residue 155, 156, or 168 of Hepatitis C Virus Genotypes 2 to 6 Induce Complex Patterns of Protease Inhibitor Resistance

Various protease inhibitors (PIs) currently are becoming available for treatment of hepatitis C virus (HCV). For genotype 1, substitutions at NS3 protease positions 155, 156, and 168 are the main determinants of PI resistance. For other genotypes, similar substitutions were selected during PI treatm...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Jensen, Sanne B., Serre, Stéphanie B. N., Humes, Daryl G., Ramirez, Santseharay, Li, Yi-Ping, Bukh, Jens, Gottwein, Judith M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4649233/
https://ncbi.nlm.nih.gov/pubmed/26392503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01953-15
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