Hepatitis C Virus Genotype 1 to 6 Protease Inhibitor Escape Variants: In Vitro Selection, Fitness, and Resistance Patterns in the Context of the Infectious Viral Life Cycle

Hepatitis C virus (HCV) NS3 protease inhibitors (PIs) are important components of novel HCV therapy regimens. Studies of PI resistance initially focused on genotype 1. Therefore, knowledge about the determinants of PI resistance for the highly prevalent genotypes 2 to 6 remains limited. Using Huh7.5...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Serre, Stéphanie B. N., Jensen, Sanne B., Ghanem, Lubna, Humes, Daryl G., Ramirez, Santseharay, Li, Yi-Ping, Krarup, Henrik, Bukh, Jens, Gottwein, Judith M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4879388/
https://ncbi.nlm.nih.gov/pubmed/27021330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02929-15
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