Adapted J6/JFH1-Based Hepatitis C Virus Recombinants with Genotype-Specific NS4A Show Similar Efficacies against Lead Protease Inhibitors, Alpha Interferon, and a Putative NS4A Inhibitor

To facilitate studies of hepatitis C virus (HCV) NS4A, we aimed at developing J6/JFH1-based recombinants with genotype 1- to 7-specific NS4A proteins. We developed efficient culture systems expressing NS4A proteins of genotypes (isolates) 1a (H77 and TN), 1b (J4), 2a (J6), 4a (ED43), 5a (SA13), 6a (...

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Detalhes bibliográficos
Main Authors: Gottwein, Judith M., Jensen, Sanne B., Serre, Stéphanie B. N., Ghanem, Lubna, Scheel, Troels K. H., Jensen, Tanja B., Krarup, Henrik, Uzcategui, Nathalie, Mikkelsen, Lotte S., Bukh, Jens
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3837860/
https://ncbi.nlm.nih.gov/pubmed/24060868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01176-13
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