Development of JFH1-based cell culture systems for hepatitis C virus genotype 4a and evidence for cross-genotype neutralization

Efficient in vitro systems to study the life cycle of hepatitis C virus (HCV) were recently developed for JFH1 (genotype 2a), which has unique replication capacity in Huh7 cells. We developed 4a/JFH1 intergenotypic recombinants containing the structural genes (Core, E1, and E2), p7, and all or part...

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Detalhes bibliográficos
Main Authors: Scheel, Troels K. H., Gottwein, Judith M., Jensen, Tanja B., Prentoe, Jannick C., Hoegh, Anne M., Alter, Harvey J., Eugen-Olsen, Jesper, Bukh, Jens
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2242719/
https://ncbi.nlm.nih.gov/pubmed/18195353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0711044105
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