Hypervariable Region 1 Differentially Impacts Viability of Hepatitis C Virus Strains of Genotypes 1 to 6 and Impairs Virus Neutralization

Hypervariable region 1 (HVR1) of hepatitis C virus (HCV) E2 envelope glycoprotein has been implicated in virus neutralization and persistence. We deleted HVR1 from JFH1-based HCV recombinants expressing Core/E1/E2/p7/NS2 of genotypes 1 to 6, previously found to grow efficiently in human hepatoma Huh...

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Detalhes bibliográficos
Main Authors: Prentoe, Jannick, Jensen, Tanja B., Meuleman, Philip, Serre, Stéphanie B. N., Scheel, Troels K. H., Leroux-Roels, Geert, Gottwein, Judith M., Bukh, Jens
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2011
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3067759/
https://ncbi.nlm.nih.gov/pubmed/21123377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01594-10
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